abstract：:Previous reports from our laboratory indicated that prophylactic protection against cyanide intoxication in mice can be enhanced by administration of chlorpromazine when it is given with sodium thiosulfate. The mechanism of potentiation of sodium thiosulfate by chlorpromazine was studied alone and in combination with ...

journal_title：Toxicology and applied pharmacology

authors： Kong A,Shen A,Burrows G,Sylvester D,Isom GE,Way JL

更新日期：1983-12-01 00:00:00

abstract：:Three major enzyme systems have been shown to metabolize epoxidized xenobiotics in vertebrate tissues, and this study demonstrates that these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrola...

journal_title：Toxicology and applied pharmacology

authors： Hammock BD,Ota K

更新日期：1983-11-01 00:00:00

abstract：:Lactate Dehydrogenase Isoenzymes in Hamster Lung Lavage Fluid after Lung Injury. Beck, B. D., Gerson, B., Feldman, H. A., and Brain, J. D. (1983). Toxicol. Appl. Pharmacol. 71, 59-71. Lactate dehydrogenase (LD) levels and isoenzyme patterns were determined in the cell-free supernatant fractions of lung lavage fluid fr...

journal_title：Toxicology and applied pharmacology

authors： Beck BD,Gerson B,Feldman HA,Brain JD

更新日期：1983-10-01 00:00:00

abstract：:The Ah locus encodes a cytosolic receptor that regulates the induction of certain drug-metabolizing enzymes by polycyclic aromatic hydrocarbons such as benzo[a]pyrene. Some inbred mouse strains such as C57BL/6N have the high-affinity Ah receptor (Ahb/Ahb), others such as DBA/2N, the poor-affinity receptor (Ahd/Ahd). P...

journal_title：Toxicology and applied pharmacology

authors： Legraverend C,Harrison DE,Ruscetti FW,Nebert DW

更新日期：1983-09-30 00:00:00

abstract：:The specificity of two major types of cytochrome P-450 of rat liver microsomes induced by phenobarbital (PB) and 3-methylcholanthrene (MC) toward activation of three 14C-labeled tetrachlorobiphenyl (TCB) isomers to protein-bound metabolites was examined by intact microsomal and reconstituted monooxygenase systems. The...

journal_title：Toxicology and applied pharmacology

authors： Shimada T,Sawabe Y

更新日期：1983-09-30 00:00:00

abstract：:A series of psychopharmacological agents were administered to adult male Fischer-344 rats pretreated with a tremorigenic dose of chlordecone in an attempt to elucidate the involvement of spinal and supraspinal processes in the mediation and/or expression of chlordecone-induced tremor. Agents effective in attenuating t...

journal_title：Toxicology and applied pharmacology

authors： Gerhart JM,Hong JS,Tilson HA

更新日期：1983-09-30 00:00:00

abstract：:Carbon disulfide is present in exposed subjects in free and bound or acid-labile forms. Sensitivities of the blood acid-labile CS2 (AL CS2) concentration and the modified iodine-azide test (IAT) were compared as indicators of CS2 exposure. Rats were exposed to 15 (approximately 5 ppm), 30, 60, or 120 mg/m3 of CS2. Exp...

journal_title：Toxicology and applied pharmacology

authors： Lam CW,DiStefano V

更新日期：1983-09-30 00:00:00

abstract：:Aroclor 1254 and fireMaster BP-6, two commercial polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) preparations, exhibit comparable biologic and toxic effects. In the present study the commercial PBB was more active than Aroclor 1254 in causing thymic atrophy in male Wistar rats. However, a direct compa...

journal_title：Toxicology and applied pharmacology

authors： Andres J,Lambert I,Robertson L,Bandiera S,Sawyer T,Lovering S,Safe S

更新日期：1983-09-15 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:Reported similarities in the acute toxic effects of 1,2-dibromo-3-chloropropane (DBCP), 3-chloro-1,2-propaneoxide (epichlorohydrin, ECH), 3-chloro-1,2-propanediol (alphachlorohydrin, ACH), and oxalic acid (OA) have been suggested as presumptive evidence that the metabolism of DBCP to OA, via ECH and ACH, is the cause ...

journal_title：Toxicology and applied pharmacology

authors： Kluwe WM,Gupta BN,Lamb JC 4th

更新日期：1983-08-01 00:00:00

abstract：:The possibility that acetaldehyde accumulation potentiates the acute toxicity of ethanol was studied by pretreating rats with cyanamide, an aldehyde dehydrogenase inhibitor. At 30 min after administration of ethanol (7 to 9 g/kg, po), the levels of acetaldehyde in femoral venous blood of cyanamide-treated rats were in...

journal_title：Toxicology and applied pharmacology

authors： Hillbom ME,Sarviharju MS,Lindros KO

更新日期：1983-08-01 00:00:00

abstract：:Administration of thiourea to mature male rats at a dosage of 3.5 mg/kg (ip) produced marked pleural effusion by 2 hr (3-4 ml). Pretreatment with bacterial lipopolysaccharide (endotoxin) significantly reduced this pleural effusion (less than 0.5 ml). Despite this unequivocal effect, there was no corresponding reductio...

journal_title：Toxicology and applied pharmacology

authors： Hollinger MA

更新日期：1983-08-01 00:00:00

abstract：:The biochemical and biological behavior of methylmercury (MeHg) was investigated by measurement of MeHg release rate from erythrocytes (RBC) of selected animal strains and species, by measurement of the intracellular distribution of MeHg in RBC, and by measurement of the binding affinity of hemoglobin (Hb) for MeHg. M...

journal_title：Toxicology and applied pharmacology

authors： Doi R,Tagawa M

更新日期：1983-07-01 00:00:00

abstract：:Two hours after a four-hour exposure to hexamethylene diisocyanate trimer (HDIt) aerosol between 2.5 and 39 mg/m3, mice were injected iv with 51Cr-EDTA (chromium ethylenediaminetetraacetate). Ten minutes later the lung was lavaged. A larger amount of 51Cr-EDTA was detected in the lung lavage of HDIt mice than of contr...

journal_title：Toxicology and applied pharmacology

authors： Valentini JE,Wong KL,Alarie Y

更新日期：1983-07-01 00:00:00

abstract：:T-2 toxin, a trichothecene mycotoxin, is a potently cytotoxic and immunosuppressive secondary metabolite produced by Fusarium fungi. Young male white Swiss mice were fed a diet supplemented with T-2 toxin at levels of 5, 10, or 20 ppm, control diet ad libitum, or control diet at a restricted rate for 1, 2, 3, 4, and 6...

journal_title：Toxicology and applied pharmacology

authors： Friend SC,Babiuk LA,Schiefer HB

更新日期：1983-06-30 00:00:00

abstract：:A comparative test in mice for pulmonary toxicity between butylated hydroxytoluene (2,6-di-tert.-butyl-4-methylphenol, BHT) and 2,6-di-tert.-butyl-4-[alpha, alpha, alpha-2H3]methylphenol (BHT-d3) showed a significantly lower toxic potency of the latter. The rate of in vitro BHT metabolism to 2,6-di-tert.-butyl-4-methy...

journal_title：Toxicology and applied pharmacology

authors： Mizutani T,Yamamoto K,Tajima K

更新日期：1983-06-30 00:00:00

abstract：:Previous work from this laboratory (J. S. Lazo, J. D. Catravas, and C. N. Gillis, Biochem. Pharmacol. 30, 2577-2584, 1981; J. D. Catraveras, J. S. Lazo, and C. N. Gillis, J. Pharmacol. Exp. Ther. 217, 524-529, 1981) demonstrated that subacute bleomycin (BLM) administration (5 mg/kg) to rabbits three times weekly for 4...

journal_title：Toxicology and applied pharmacology

authors： Lazo JS,Catravas JD,Dobuler KJ,Gillis CN

更新日期：1983-06-30 00:00:00

abstract：:Prior consumption of a diet containing the food antioxidant, butylated hydroxyanisole (BHA), by female mice prevented the development of or minimized the acute liver damage caused by monocrotaline, acetaminophen, or bromobenzene. In contrast, neither the incidence nor the severity of carbon tetrachloride-induced hepat...

journal_title：Toxicology and applied pharmacology

authors： Miranda CL,Henderson MC,Schmitz JA,Buhler DR

更新日期：1983-06-15 00:00:00

abstract：:The disappearance rate of renin from plasma was evaluated in both acutely and chronically lead-exposed rabbits. In addition, the effects of lead (Pb) on in vitro renin secretion were determined with rabbit renal cortical slices. Rabbits acutely exposed to Pb (0.3 to 2.0 mg/kg, iv) demonstrated no increase in plasma re...

journal_title：Toxicology and applied pharmacology

authors： Keiser JA,Vander AJ,Germain CL

更新日期：1983-06-15 00:00:00

abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

journal_title：Toxicology and applied pharmacology

authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

更新日期：1983-06-15 00:00:00

abstract：:Methyl chloride (MeCl) metabolism and pharmacokinetics were studied in male Fischer 344 rats and male beagle dogs. Apparent steady-state blood MeCl concentrations were proportionate to exposure concentration in rats and dogs exposed to 50 and 1000 ppm. Furthermore, blood MeCl concentrations were similar in both specie...

journal_title：Toxicology and applied pharmacology

authors： Landry TD,Gushow TS,Langvardt PW,Wall JM,McKenna MJ

更新日期：1983-05-01 00:00:00

abstract：:Technical grade dinitrotoluene (DNT) is hepatocarcinogenic when fed to rats. DNT is oxidatively metabolized by hepatic enzymes and reductively metabolized by rat intestinal microflora in vitro. The objectives of the present studies were to determine the importance of bile as a route of excretion for DNT metabolites an...

journal_title：Toxicology and applied pharmacology

authors： Medinsky MA,Dent JG

更新日期：1983-05-01 00:00:00

abstract：:These studies were initiated to determine (1) if cisplatin (cis-DDP)-induced hyperglucagonemia is related to decreased hormone degradation, (2) the relationship between impaired kidney function associated with cis-DDP nephrotoxicity and hyperglucagonemia, and (3) the contribution of cis-DDP-induced hyperglucagonemia t...

journal_title：Toxicology and applied pharmacology

authors： Goldstein RS,Mayor GH,Gingerich RL,Hook JB,Robinson B,Bond JT

更新日期：1983-04-01 00:00:00

abstract：:In a previous study, we demonstrated that parathion suppressed both the primary IgM and IgG response to sheep erythrocytes (SRC) in inbred and outbred mice (G. P. Casale, S. D. Cohen, and R. A. DiCapua, 1982, toxicologist 2, 94). Suppression occurred after a dosage which produced cholinergic effects but was absent aft...

journal_title：Toxicology and applied pharmacology

authors： Casale GP,Cohen SD,DiCapua RA

更新日期：1983-04-01 00:00:00

abstract：:Acrylonitrile (VCN) is a heavily used monomer in plastic and fiber industries. Quantitatively, VCN-induced gastrointestinal hemorrhage is time and dose dependent and is not the result of a direct irritating action of VCN on gastric tissues. The effect of cytochrome P-450 enzymes inducers was studied. Pretreatment with...

journal_title：Toxicology and applied pharmacology

authors： Ghanayem BI,Ahmed AE

更新日期：1983-04-01 00:00:00

abstract：:A mass-balance study was undertaken to evaluate the accuracy of dose determinations of waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl (TCB) made on transected brook trout (Salvelinus fontinalis) and rainbow trout (Salmo gairdneri) and to determine any pharmacokinetic differences between the two species. The total calcu...

journal_title：Toxicology and applied pharmacology

authors： McKim JM,Heath EM

更新日期：1983-04-01 00:00:00

abstract：:Female Golden Syrian hamsters, F-344 rats, Swiss CD-1 mice, and B6C3F1 hybrid mice were exposed 6 hr/day, 5 days/week to carcinogenic levels of vinyl chloride (VC) for 6, 12, 18, or 24 months (rats and hamsters only). Other groups of rodents were held for 6 or 12 months and then exposed for 6 or 12 months. At the end ...

journal_title：Toxicology and applied pharmacology

authors： Drew RT,Boorman GA,Haseman JK,McConnell EE,Busey WM,Moore JA

更新日期：1983-03-30 00:00:00

abstract：:Inoculation of metallic tin powder produced marked proliferation of plasma cells and Russell body cells in draining lymph nodes. Prior, but not concurrent, administration of a soluble tin salt in the drinking water prevented the plasma cell hyperplasia. Various Na, Zn, Ag, and Cu salts were not inhibitory. The inhibit...

journal_title：Toxicology and applied pharmacology

authors： Levine S,Sowinski R

更新日期：1983-03-30 00:00:00

abstract：:This study was undertaken to characterize the long-term toxic and carcinogenic potential of a polybrominated biphenyl (PBB) mixture in rats and mice of both sexes. Fischer 344 rats and B6C3F1 mice were given 125 po doses of PBB over a 6-month period at 0 (control), 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg body weight/day (5...

journal_title：Toxicology and applied pharmacology

authors： Gupta BN,McConnell EE,Moore JA,Haseman JK

更新日期：1983-03-30 00:00:00

abstract：:Radiolabeled 1-naphthyl-beta-D-glucuronide and 1-naphthyl-beta-D-glucoside were synthesized from 1-[14C]naphthol. The fate of the three compounds in male mice was studied. After a po dose of 45 mg/kg of 1-naphthol, 100 mg/kg of 1-naphthyl glucuronide, and 100 mg/kg of 1-naphthyl glucoside, 95, 93, and 81%, respectivel...

journal_title：Toxicology and applied pharmacology

authors： Chern WH,Dauterman WC

更新日期：1983-03-15 00:00:00

abstract：:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1983-03-15 00:00:00

abstract：:Rats received one or two consecutive daily ip injections, each 0.5 mg Pb2+/100 g body weight, and the kidneys were studied 48 or 24 hr, respectively, after the injection. Renal brush border preparations from Pb2+-treated rats exhibited significant decreases in the activity of alanine aminopeptidase and gamma-glutamyl ...

journal_title：Toxicology and applied pharmacology

authors： Nicholls DM,Teichert-Kuliszewska K,Kuliszewski MJ

更新日期：1983-02-01 00:00:00

abstract：:The utility of isolated rat hepatocytes as a model system for screening potential chelators in treatment of Cd intoxication was studied. The ability of the chelators diethylenetriaminepentaacetic acid (DTPA), ethylenediaminetetraacetic acid (EDTA), 2,3-dimercaptosuccinic acid (DMSA), diethyldithiocarbamic acid (DDC), ...

journal_title：Toxicology and applied pharmacology

authors： Cantilena LR Jr,Stacey NH,Klaassen CD

更新日期：1983-02-01 00:00:00

abstract：:Female Sprague-Dawley rats were treated with a single ip dose of aflatoxin B1 (AFB1) (3 or 6 mg/kg). Twenty-four hours later and weekly until killed, some of the rats treated with AFB1 were given ethynylestradiol (EE) by gavage at the dose of 13 mg/kg. One, three, six, and nine months following the beginning of the ex...

journal_title：Toxicology and applied pharmacology

authors： Kamdem L,Magdalou J,Siest G,Ban M,Zissu D

更新日期：1983-01-01 00:00:00